Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Il6tm1Kopf
Name:	interleukin 6; targeted mutation 1, Manfred Kopf
MGI ID:	MGI:1857197
Synonyms:	Il6-, IL-6-, IL-6 KO, Il6tm1Koe, Il6tm1Kopf
Gene:	Il6  Location: Chr5:30218112-30224973 bp, + strand  Genetic Position: Chr5, 15.7 cM
Alliance:	Il6tm1Kopf page

Germline Transmission:	Earliest citation of germline transmission: J:17360
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection cassette was inserted into exon 2. RT-PCR experiments on RNA derived from LPS-stimulated macrophages of homozygous mice demonstrated that no detectable transcript was produced from this allele. ELISA and bioassay experiments confirmed that no functional protein was made in homozygous mice. (J:17360)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	20 anatomical structure(s)

List all tumor models in MMHCdb carrying Il6tm1Kopf

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 9 strains available      Cell Lines: 0 lines available
Carrying any Il6 Mutation:	38 strains or lines available

Original:	J:17360 Kopf M, et al., Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature. 1994 Mar 24;368(6469):339-42
All:	707 reference(s)