Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Il10tm1Cgn Name: interleukin 10; targeted mutation 1, University of Cologne MGI ID: MGI:1857199 Synonyms: Il10-, IL-10-, IL-10 KO, IL-10KO, IL-10KO, Il10tmCgn Gene: Il10  Location: Chr1:130947582-130952711 bp, + strand  Genetic Position: Chr1, 56.89 cM Alliance: Il10tm1Cgn page

Characterization of Il10tm1Cgn/Il10tm1Cgn mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:15222
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 500 bp genomic fragment containing codons 5-55 was replaced with a linker containing a termination codon followed by a neomycin cassette. A termination codon was also introduced into exon 3. No IL10 activity was detectable by ELISA assays in supernatants of in vitro cultures of Con A-stimulated splenic T cells derived from homozygous mice following infection with the nematode N. brasiliensis. (J:15222)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	26 anatomical structure(s)

List all tumor models in MMHCdb carrying Il10tm1Cgn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 15 strains available      Cell Lines: 0 lines available
Carrying any Il10 Mutation:	45 strains or lines available

Original:	J:15222 Kuhn R, et al., Interleukin-10-deficient mice develop chronic enterocolitis [see comments]. Cell. 1993 Oct 22;75(2):263-74
All:	1033 reference(s)