Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol: Ldlrtm1Her Name: low density lipoprotein receptor; targeted mutation 1, Joachim Herz MGI ID: MGI:1857212 Synonyms: Ldlr-, LDLR-, LDLr0, LDLr-KO, LDLrKO, LDLR KO, Ldlrtm1Her Gene: Ldlr  Location: Chr9:21634872-21661215 bp, + strand  Genetic Position: Chr9, 7.87 cM Alliance: Ldlrtm1Her page

Phenotype of aortic arch atherosclerotic lesions in Tbx21tm1Glm/Tbx21tm1Glm Ldlrtm1Her/Ldlrtm1Her and Ldlrtm1Her/Ldlrtm1Her mice Show the 9 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:37394
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a neomycin resistance cassette into exon 4. The authors predict that the targeted allele would encode a truncated non-functional protein that will not bind LDL, and that lacks a membrane spanning segment. Immunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals. (J:37394)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	14 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 19 strains available      Cell Lines: 0 lines available
Carrying any Ldlr Mutation:	81 strains or lines available

Original:	J:37394 Ishibashi S, et al., Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments]. J Clin Invest. 1993 Aug;92(2):883-93
All:	1410 reference(s)