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Ltatm1Dch
Targeted Allele Detail
Summary
Symbol: Ltatm1Dch
Name: lymphotoxin A; targeted mutation 1, David D Chaplin
MGI ID: MGI:1857215
Synonyms: LT-, Lta-, LT-alpha-, LTalpha-
Gene: Lta  Location: Chr17:35422141-35424327 bp, - strand  Genetic Position: Chr17, 18.59 cM
Alliance: Ltatm1Dch page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17976
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a small portion of exon 2, all of exon 3, and a small portion of exon 4. (J:17976, J:95222, J:110548)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 14 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Lta Mutation:  17 strains or lines available
References
Original:  J:17976 De Togni P, et al., Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin [see comments]. Science. 1994 Apr 29;264(5159):703-7
All:  181 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory