Myod1<tm1Jae> Targeted Allele Detail MGI Mouse (MGI:1857221)

Myod1^tm1Jae
Targeted Allele Detail

Summary

Symbol:	Myod1^tm1Jae
Name:	myogenic differentiation 1; targeted mutation 1, Rudolf Jaenisch
MGI ID:	MGI:1857221
Synonyms:	MyoD (-), MyoD-, MyoD^ml
Gene:	Myod1 Location: Chr7:46025898-46028516 bp, + strand Genetic Position: Chr7, 30.03 cM
Alliance:	Myod1^tm1Jae page

Dmd^mdx/? Myod1^tm1Jae/Myod1^tm1Jae mice develop cardiomyopathy

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:3070
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Replacement of the MyoD promoter, exon 1 and half of intron 1 with a neomycin cassette. (J:3070)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

355 assay results
1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Myod1 Mutation:	23 strains or lines available

References

Original:	J:3070 Rudnicki MA, et al., Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development. Cell. 1992 Oct 30;71(3):383-90
All:	82 reference(s)

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