Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Nos2tm1Lau
Name:	nitric oxide synthase 2, inducible; targeted mutation 1, Victor E Laubach
MGI ID:	MGI:1857228
Synonyms:	iNOS-, iNOS-, iNOS KO, NOS2-, Nos2tm1Lau, NOS2tm/Lau
Gene:	Nos2  Location: Chr11:78811613-78851052 bp, + strand  Genetic Position: Chr11, 46.74 cM
Alliance:	Nos2tm1Lau page

Germline Transmission:	Earliest citation of germline transmission: J:29677
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin cassette replaced exons 12 and 13 of the gene, which encode the calmodulin-binding domain. Northern and Western blots of IFNg/LPS-stimulated peritoneal macrophages showed no detectable Nos2 mRNA or protein, respectively. (J:29677, J:183641)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	22 anatomical structure(s)

List all tumor models in MMHCdb carrying Nos2tm1Lau

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 8 strains available      Cell Lines: 0 lines available
Carrying any Nos2 Mutation:	67 strains or lines available

Original:	J:29677 Laubach VE, et al., Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10688-92
All:	506 reference(s)