Src<tm1Sor> Targeted Allele Detail MGI Mouse (MGI:1857247)

Src^tm1Sor
Targeted Allele Detail

Summary

Symbol:	Src^tm1Sor
Name:	Rous sarcoma oncogene; targeted mutation 1, Philippe Soriano
MGI ID:	MGI:1857247
Synonyms:	src^-
Gene:	Src Location: Chr2:157265828-157313758 bp, + strand Genetic Position: Chr2, 78.35 cM
Alliance:	Src^tm1Sor page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:67040
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A neomycin cassette was inserted into the first coding exon. Northern blot analysis confirmed that no wild-type transcript was present in homozygous mice. No autophosphorylation activity corresponding to the encoded protein is detectable in homozygous mice. (J:67040)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Src^tm1Sor

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Src Mutation:	146 strains or lines available

References

Original:	J:67040 Soriano P, et al., Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell. 1991 Feb 22;64(4):693-702
All:	74 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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