About   Help   FAQ
Stat5atm1Mam
Targeted Allele Detail
Summary
Symbol: Stat5atm1Mam
Name: signal transducer and activator of transcription 5A; targeted mutation 1, Lothar Hennighausen
MGI ID: MGI:1857249
Synonyms: Stat5a-
Gene: Stat5a  Location: Chr11:100750177-100775995 bp, + strand  Genetic Position: Chr11, 63.77 cM
Alliance: Stat5atm1Mam page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64278
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The promoter sequence, an untranslated exon, and two coding exons were replaced by a neomycin selection cassette. Western blot analysis of extracts immunoprecipitated from mammary tissue of homozygous mutant mice showed an absence of encoded protein. (J:64278)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 416144 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Stat5a Mutation:  48 strains or lines available
References
Original:  J:64278 Liu X, et al., Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 1997 Jan 15;11(2):179-86
All:  38 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory