Ttr<tm1Wsb> Targeted Allele Detail MGI Mouse (MGI:1857264)

About Help FAQ

Ttr^tm1Wsb
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Ttr^tm1Wsb
Name:	transthyretin; targeted mutation 1, William S Blaner
MGI ID:	MGI:1857264
Synonyms:	ttr^-, TTR KO
Gene:	Ttr Location: Chr18:20798337-20807378 bp, + strand Genetic Position: Chr18, 11.47 cM
Alliance:	Ttr^tm1Wsb page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:4183
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1^c

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: Insertion of a neomycin resistance cassette into the second exon disrupted the gene. Western blot analysis of peripheral blood using a rat polyclonal antiserum did not detect protein in homozygous mutant mice. (J:4183)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ttr Mutation:	46 strains or lines available

References

Original:	J:4183 Episkopou V, et al., Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2375-9
All:	47 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24