Ttr<tm1Wsb> Targeted Allele Detail MGI Mouse (MGI:1857264)

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Ttr^tm1Wsb
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Ttr^tm1Wsb
Name:	transthyretin; targeted mutation 1, William S Blaner
MGI ID:	MGI:1857264
Synonyms:	ttr^-, TTR KO
Gene:	Ttr Location: Chr18:20798337-20807378 bp, + strand Genetic Position: Chr18, 11.47 cM
Alliance:	Ttr^tm1Wsb page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:4183
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1^c

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: Insertion of a neomycin resistance cassette into the second exon disrupted the gene. Western blot analysis of peripheral blood using a rat polyclonal antiserum did not detect protein in homozygous mutant mice. (J:4183)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ttr Mutation:	46 strains or lines available

References

Original:	J:4183 Episkopou V, et al., Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2375-9
All:	47 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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