Cdh1<tm1Kem> Targeted Allele Detail MGI Mouse (MGI:1857282)

Cdh1^tm1Kem
Targeted Allele Detail

Summary

Symbol:	Cdh1^tm1Kem
Name:	cadherin 1; targeted mutation 1, Rolf Kemler
MGI ID:	MGI:1857282
Synonyms:	E-cad-
Gene:	Cdh1 Location: Chr8:107329983-107396878 bp, + strand Genetic Position: Chr8, 53.18 cM, cytoband D
Alliance:	Cdh1^tm1Kem page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:19904
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutation:		Insertion
		Mutation details: A lacZ gene and neomycin resistance cassette was inserted into exon 1 just upstream of the initiation codon of the gene. (J:19904)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Cdh1^tm1Kem

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Cdh1 Mutation:	173 strains or lines available

References

Original:	J:19904 Larue L, et al., E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8263-7
All:	12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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