Plg<tm1Jld> Targeted Allele Detail MGI Mouse (MGI:1857291)

Plg^tm1Jld
Targeted Allele Detail

Summary

Symbol:	Plg^tm1Jld
Name:	plasminogen; targeted mutation 1, Jay L Degen
MGI ID:	MGI:1857291
Synonyms:	Plg^-, Plg⁰
Gene:	Plg Location: Chr17:12597496-12638271 bp, + strand Genetic Position: Chr17, 8.5 cM
Alliance:	Plg^tm1Jld page

Gross appearance of aortic arches of Apoe^tm1Bres/Apoe^tm1Bres, Plg^tm1Jld/Plg^tm1Jld and Apoe^tm1Bres/Apoe^tm1Bres Plg^tm1Jld/Plg^tm1Jld mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:39419
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A PGK-HPRT minigene replaces proximal promoter sequences and the first two exons of the gene. Northern analysis and enzymatic activity assays were used to demonstrate the lack of a transcript and functional protein, respectively, in homozygous mutant animals. (J:39419)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Plg^tm1Jld

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Plg Mutation:	5 strains or lines available

References

Original:	J:39419 Bugge TH, et al., Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes Dev. 1995 Apr 1;9(7):794-807
All:	76 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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