Hoxb4<tm1Bay> Targeted Allele Detail MGI Mouse (MGI:1857390)

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Hoxb4^tm1Bay
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Hoxb4^tm1Bay
Name:	homeobox B4; targeted mutation 1, Baylor College of Medicine
MGI ID:	MGI:1857390
Synonyms:	hoxb-4^r
Gene:	Hoxb4 Location: Chr11:96209093-96212464 bp, + strand Genetic Position: Chr11, 59.83 cM
Alliance:	Hoxb4^tm1Bay page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:4612
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Insertion of a gpt and neomycin cassette into exon 1. (J:4612)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Hoxb4 Mutation:	20 strains or lines available

References

Original:	J:4612 Ramirez-Solis R, et al., Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments. Cell. 1993 Apr 23;73(2):279-94
All:	5 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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