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Emx1tm1Jlr
Targeted Allele Detail
Summary
Symbol: Emx1tm1Jlr
Name: empty spiracles homeobox 1; targeted mutation 1, John Rubenstein
MGI ID: MGI:1857433
Synonyms: Emx-1-, Emx1null
Gene: Emx1  Location: Chr6:85164913-85181445 bp, + strand  Genetic Position: Chr6, 37.21 cM
Alliance: Emx1tm1Jlr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:35060
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Insertion of a PGK-neomycin resistance cassette replaced exon 1 and part of intron 1 of the Emx1 gene. Northern analysis of E14.5 embryos did not detect Emx1 transcript in homozygous mutant mice. The authors predict that the mutant allele would produce a truncated protein that lacks the N-terminus. (J:35060)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 37 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Emx1 Mutation:  34 strains or lines available
References
Original:  J:35060 Qiu M, et al., Mutation of the Emx-1 homeobox gene disrupts the corpus callosum. Dev Biol. 1996 Aug 25;178(1):174-8
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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11/19/2024
MGI 6.24 		The Jackson Laboratory