Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Ptch1tm1Mps Name: patched 1; targeted mutation 1, Matthew P Scott MGI ID: MGI:1857447 Synonyms: LacZ/Ptc, ptc-, Ptc1-, Ptc1-lacZ, Ptc1lzki, Ptch-, Ptch1-, Ptch1-lacZ, PtchKO1, PtchlacZ, ptc-lacZ, PtclacZ, Ptcn Gene: Ptch1  Location: Chr13:63656142-63721274 bp, - strand  Genetic Position: Chr13, 32.8 cM Alliance: Ptch1tm1Mps page

Skeletal abnormalities in Ptch1dl/Ptch1tm1Mps mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:42441
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A construct containing a promoterless lacZ-neo fusion gene was inserted at the start codon and deleted a portion of exon 1 and all of exon 2, which encoded the first transmembrane domain. Expression of the inserted lacZ gene served as an accurate reporter in heterozygotes but was found to be derepressed in homozygous mutant mice. (J:42441)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	347 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	17 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptch1tm1Mps

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ptch1 Mutation:	115 strains or lines available

Original:	J:42441 Goodrich LV, et al., Altered neural cell fates and medulloblastoma in mouse patched mutants. Science. 1997 Aug 22;277(5329):1109-13
All:	336 reference(s)