Ciita<tm1Ccum> Targeted Allele Detail MGI Mouse (MGI:1857456)

Ciita^tm1Ccum
Targeted Allele Detail

Summary

Symbol:	Ciita^tm1Ccum
Name:	class II transactivator; targeted mutation 1, Cheong-Hee Chang
MGI ID:	MGI:1857456
Synonyms:	C2ta^tm1Ccum, CIITA-, CIITA C^-, MHC classII^-
Gene:	Ciita Location: Chr16:10297923-10346282 bp, + strand Genetic Position: Chr16, 5.65 cM, cytoband B1
Alliance:	Ciita^tm1Ccum page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:31601
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A genomic fragment containing exons which encode critical regions of the protein was replaced with a neomycin selection gene. Northern blot analysis on RNA derived from homozygous mice demonstrated that no detectable protein was produced from this allele. (J:31601)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available Cell Lines: 0 lines available
Carrying any Ciita Mutation:	46 strains or lines available

References

Original:	J:31601 Chang CH, et al., Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. Immunity. 1996 Feb;4(2):167-78
All:	67 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24