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Fgf2tm1Doe
Targeted Allele Detail
Summary
Symbol: Fgf2tm1Doe
Name: fibroblast growth factor 2; targeted mutation 1, Thomas Doetschman
MGI ID: MGI:1857458
Synonyms: Fgf2-, FGF-2-
Gene: Fgf2  Location: Chr3:37402616-37464255 bp, + strand  Genetic Position: Chr3, 18.41 cM, cytoband A2-B
Alliance: Fgf2tm1Doe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45775
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: An Hprt minigene replaced 0.5kb of sequence containing 121bp of the proximal promoter region and exon 1. Northern blot analysis of E13.5 embryos demonstrated that no mRNA containing exon 2 and 3 sequences is detectable in homozygous mutant mice. Western blot analysis on brain tissue from homozygous mutant mice showed that the protein is absent. (J:45775)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 24 assay results
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgf2 Mutation:  19 strains or lines available
References
Original:  J:45775 Zhou M, et al., Fibroblast growth factor 2 control of vascular tone. Nat Med. 1998 Feb;4(2):201-7
All:  54 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory