Fst<tm1Zuk> Targeted Allele Detail MGI Mouse (MGI:1857467)

Fst^tm1Zuk
Targeted Allele Detail

Summary

Symbol:	Fst^tm1Zuk
Name:	follistatin; targeted mutation 1, Martin M Matzuk
MGI ID:	MGI:1857467
Synonyms:	fs^m1, Fst-, Fst^tm1
Gene:	Fst Location: Chr13:114588826-114595487 bp, - strand Genetic Position: Chr13, 64.15 cM
Alliance:	Fst^tm1Zuk page

Axial skeleton patterning defects in Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl, Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Fst^tm1Zuk/Fst^tm1Zuk, Gdf11^tm1Sjl/Gdf11⁺ and Gdf11^tm1Sjl/Gdf11^tm1Sjl mice.

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:23925
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		An Hprt expression cassette replaced the entire gene, including all 6 exons. (J:23925)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	63 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	23 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Fst Mutation:	19 strains or lines available

References

Original:	J:23925 Matzuk MM, et al., Multiple defects and perinatal death in mice deficient in follistatin [see comments]. Nature. 1995 Mar 23;374(6520):360-3
All:	29 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24