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Tnfrsf1atm1Imx
Targeted Allele Detail
Summary
Symbol: Tnfrsf1atm1Imx
Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 1, Immunex Research and Development Corporation
MGI ID: MGI:1857468
Synonyms: p55-, p55 KO, Preschon Tnfrsf1a-, TNF-alpha-R1, TNFR-, TNFR1-, TNFRI-, Tnfrsf1atm1Imx
Gene: Tnfrsf1a  Location: Chr6:125326686-125339446 bp, + strand  Genetic Position: Chr6, 59.32 cM
Alliance: Tnfrsf1atm1Imx page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45147
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A PGK-neomycin resistance cassette replaced 4kb of sequence, including exons 2 to 5 (amino acids 30 - 184). Lack of gene product was shown functionally. (J:45147, J:110548)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 81 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf1a Mutation:  52 strains or lines available
References
Original:  J:45147 Peschon JJ, et al., TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol. 1998 Jan 15;160(2):943-52
All:  407 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory