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Ednratm1Ywa
Targeted Allele Detail
Summary
Symbol: Ednratm1Ywa
Name: endothelin receptor type A; targeted mutation 1, Masashi Yanagisawa
MGI ID: MGI:1857473
Synonyms: ET/A -
Gene: Ednra  Location: Chr8:78389658-78451081 bp, - strand  Genetic Position: Chr8, 36.63 cM, cytoband C2
Alliance: Ednratm1Ywa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46639
Parent Cell Line:  JH1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 5 and 6, which encode the sixth and seventh transmembrane domains of the protein. Radioligand binding assays on samples derived from skin of homozygous embryos demonstrated that no functional protein was produced from this allele. (J:46639)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 153 assay results
In Structures Affected by this Mutation: 47 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ednra Mutation:  35 strains or lines available
References
Original:  J:46639 Clouthier DE, et al., Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development. 1998 Mar;125(5):813-24
All:  16 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory