Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Nf1tm1Tyj
Name:	neurofibromin 1; targeted mutation 1, Tyler Jacks
MGI ID:	MGI:1857478
Synonyms:	Nf1-, Nf1n31
Gene:	Nf1  Location: Chr11:79230519-79472438 bp, + strand  Genetic Position: Chr11, 46.74 cM, cytoband B4-5
Alliance:	Nf1tm1Tyj page

Germline Transmission:	Earliest citation of germline transmission: J:18542
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced the first 42 codons of exon 31, the exon 31 splice acceptor site, and approximately 2 kb of intron 30. This allele is a null allele; no stable full-length protein is made. (J:18542)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

List all tumor models in MMHCdb carrying Nf1tm1Tyj

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nf1 Mutation:	161 strains or lines available

Original:	J:18542 Jacks T, et al., Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat Genet. 1994 Jul;7(3):353-61
All:	96 reference(s)