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Alx4tm1Rwi
Targeted Allele Detail
Summary
Symbol: Alx4tm1Rwi
Name: aristaless-like homeobox 4; targeted mutation 1, Ronald Wisdom
MGI ID: MGI:1857484
Synonyms: Alx-4-, Alx-4tm1qw
Gene: Alx4  Location: Chr2:93472779-93511686 bp, + strand  Genetic Position: Chr2, 51.62 cM
Alliance: Alx4tm1Rwi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43769
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: A neomycin resistance cassette was inserted into sequences encoding the recognition helix of the homeobox domain. Western blot analysis on nuclear extracts derived from E10.5 embryos indicated that the protein is absent in homozygous mice. (J:43769)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Alx4 Mutation:  21 strains or lines available
References
Original:  J:43769 Qu S, et al., Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development. 1997 Oct;124(20):3999-4008
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory