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Nkx2-1tm1Shk
Targeted Allele Detail
Summary
Symbol: Nkx2-1tm1Shk
Name: NK2 homeobox 1; targeted mutation 1, Shioko Kimura
MGI ID: MGI:1857494
Synonyms: Nkx2.1-, T/EBP/NKX2.1-null, T/ebp null, Titf1-
Gene: Nkx2-1  Location: Chr12:56578741-56583570 bp, - strand  Genetic Position: Chr12, 24.42 cM, cytoband C1-C3
Alliance: Nkx2-1tm1Shk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:30559
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: Insertion of a neomycin resistance cassette into the second exon of the gene disrupted the first helix of the homeo domain sequence. (J:30559)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 196 assay results
In Structures Affected by this Mutation: 24 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkx2-1 Mutation:  24 strains or lines available
References
Original:  J:30559 Kimura S, et al., The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev. 1996 Jan 1;10(1):60-9
All:  48 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory