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Hoxa1tm1Ipc
Targeted Allele Detail
Summary
Symbol: Hoxa1tm1Ipc
Name: homeobox A1; targeted mutation 1, Pierre Chambon
MGI ID: MGI:1857504
Synonyms: Hox-1.6-, Hoxa1null, Hoxa-1tot
Gene: Hoxa1  Location: Chr6:52132573-52135299 bp, - strand  Genetic Position: Chr6, 25.4 cM
Alliance: Hoxa1tm1Ipc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23837
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of nucleotides -49 to +373 relative to the transcription initiation site with a neomycin cassette. (J:23837)
Inheritance:    Recessive
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: 129S2/SvPas
 
involves: 129S2/SvPas * C57BL/6
 
involves: 129S2/SvPas * 129S7/SvEvBrd
 
Phenotypes:
Affected Systems
show or hide all annotated terms
     
cellular
abnormal neural crest cell migration
abnormal neural crest cell delamination
craniofacial
abnormal basioccipital bone morphology
abnormal interparietal bone morphology
abnormal exoccipital bone morphology
embryo
embryo phenotype
N
abnormal neural crest cell migration
abnormal neural crest cell delamination
delayed neural tube closure
abnormal rhombomere morphology
decreased rhombomere 4 size
decreased rhombomere 5 size
abnormal rhombomere boundary morphology
hearing/vestibular/ear
abnormal otic vesicle morphology
small otic vesicle
abnormal inner ear morphology
abnormal cochlea morphology
abnormal cochlear sensory epithelium morphology
absent cochlea
absent common crus
absent posterior semicircular canal
abnormal crista ampullaris morphology
absent superior semicircular canal
absent semicircular canals
abnormal inner ear vestibule morphology
abnormal membranous labyrinth morphology
absent scala media
abnormal utricular macula morphology
absent utricle
abnormal vestibular saccular macula morphology
absent vestibular saccule
absent endolymphatic duct
absent endolymphatic sac
abnormal otic capsule morphology
abnormal tympanic ring morphology
homeostasis/metabolism
cyanosis
anoxia
mortality/aging
perinatal lethality, complete penetrance
muscle
N
muscle phenotype
N
muscle spasm
nervous system
delayed neural tube closure
abnormal rhombomere morphology
decreased rhombomere 4 size
decreased rhombomere 5 size
abnormal rhombomere boundary morphology
abnormal hindbrain morphology
absent facial nuclei
abnormal cranial ganglia morphology
absent cochlear ganglion
abnormal superior vagus ganglion morphology
small vestibular ganglion
abnormal cranial nerve morphology
absent facial nerve
abnormal glossopharyngeal nerve morphology
abnormal vagus nerve morphology
absent vestibulocochlear nerve
respiratory system
respiratory failure
skeleton
abnormal basioccipital bone morphology
abnormal interparietal bone morphology
abnormal exoccipital bone morphology
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 366 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 35 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa1 Mutation:  14 strains or lines available
References
Original:  J:23837 Lufkin T, et al., Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell. 1991 Sep 20;66(6):1105-19
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory