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Otx2tm1Pas
Targeted Allele Detail
Summary
Symbol: Otx2tm1Pas
Name: orthodenticle homeobox 2; targeted mutation 1, Institut Pasteur
MGI ID: MGI:1857510
Synonyms: Otx2-, Otx2lacZ
Gene: Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance: Otx2tm1Pas page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29276
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation details: A lacZ gene and neomycin cassette were inserted in-frame into the gene at a position 213 nucleotides upstream of the translation initiation site. A beta-galactosidase protein is expressed from this allele under the control of the endogenous promoter. (J:29276)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 234 assay results
In Structures Affected by this Mutation: 18 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:  50 strains or lines available
References
Original:  J:29276 Acampora D, et al., Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 1995 Oct;121(10):3279-90
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory