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Tlx2tm1Ut
Targeted Allele Detail
Summary
Symbol: Tlx2tm1Ut
Name: T cell leukemia, homeobox 2; targeted mutation 1, University of Toronto
MGI ID: MGI:1857514
Synonyms: Tlx-2-
Gene: Tlx2  Location: Chr6:83045306-83047206 bp, - strand  Genetic Position: Chr6, 35.94 cM, cytoband C3-D1
Alliance: Tlx2tm1Ut page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48372
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A lacZ sequence and neomycin resistance cassette replaced most of the first exon, starting at the initiation codon. (J:48372)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlx2 Mutation:  12 strains or lines available
References
Original:  J:48372 Tang SJ, et al., The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development. 1998 May;125(10):1877-87
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory