Jup<tm1Kem> Targeted Allele Detail MGI Mouse (MGI:1857539)

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Jup^tm1Kem
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Jup^tm1Kem
Name:	junction plakoglobin; targeted mutation 1, Rolf Kemler
MGI ID:	MGI:1857539
Synonyms:	Pg-, plako-
Gene:	Jup Location: Chr11:100259784-100288589 bp, - strand Genetic Position: Chr11, 63.47 cM
Alliance:	Jup^tm1Kem page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:38047
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		A neomycin resistance cassette replaced exons 3 and 4 of the gene. (J:38047)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	32 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Jup Mutation:	162 strains or lines available

References

Original:	J:38047 Bierkamp C, et al., Embryonic heart and skin defects in mice lacking plakoglobin. Dev Biol. 1996 Dec 15;180(2):780-5
All:	7 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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