Zfpm1<tm1Sho> Targeted Allele Detail MGI Mouse (MGI:1857554)

Zfpm1^tm1Sho
Targeted Allele Detail

Summary

Symbol:	Zfpm1^tm1Sho
Name:	zinc finger protein, multitype 1; targeted mutation 1, Stuart Orkin
MGI ID:	MGI:1857554
Synonyms:	FOG-1^-
Gene:	Zfpm1 Location: Chr8:123008880-123063990 bp, + strand Genetic Position: Chr8, 70.86 cM, cytoband E1
Alliance:	Zfpm1^tm1Sho page

Cardiac defects in Zfpm1^tm1Sho/Zfpm1^tm1Sho Tg(Gata1-Zfpm1)1Sho mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:47281
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Sequence encoding the first 7 of 9 zinc finger domains was deleted by the insertion of a neomycin selection cassette. (J:47281)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Zfpm1 Mutation:	33 strains or lines available

References

Original:	J:47281 Tsang AP, et al., Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev. 1998 Apr 15;12(8):1176-88
All:	4 reference(s)

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