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Klf1tm1Nimr
Targeted Allele Detail
Summary
Symbol: Klf1tm1Nimr
Name: Kruppel-like transcription factor 1 (erythroid); targeted mutation 1, National Institute of Medical Research
MGI ID: MGI:1857557
Synonyms: EKLF-
Gene: Klf1  Location: Chr8:85628611-85631920 bp, + strand  Genetic Position: Chr8, 41.3 cM
Alliance: Klf1tm1Nimr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:25650
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation details: A LacZ gene and neomycin resistance cassette was inserted in-frame into the genomic sequence just after the initiator ATG codon. This allele expresses beta-galactosidase under the control of the endogenous promoter. (J:25650)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 21 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf1 Mutation:  22 strains or lines available
References
Original:  J:25650 Nuez B, et al., Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature. 1995 May 25;375(6529):316-8
All:  10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory