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Apobtm3Sgy
Targeted Allele Detail
Summary
Symbol: Apobtm3Sgy
Name: apolipoprotein B; targeted mutation 3, Stephen G Young
MGI ID: MGI:1857625
Synonyms: apoB-
Gene: Apob  Location: Chr12:8027648-8066835 bp, + strand  Genetic Position: Chr12, 3.53 cM
Alliance: Apobtm3Sgy page
The yolk sac visceral endoderm from Apobtm3Sgy/Apobtm3Sgy embryos contains foamy vacuoles

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23315
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: A sequence-insertion vector was used to interrupt the coding sequence after exon 4 and is predicted to result in a truncated protein produced from this allele. (J:23315)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apob Mutation:  224 strains or lines available
Notes
The presence of Tg(APOB)1102Sgy (J:81265) prevented the lethal developmental abnormalities caused by this allele.
References
Original:  J:23315 Farese RV Jr, et al., Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1774-8
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory