Bmi1<tm1Brn> Targeted Allele Detail MGI Mouse (MGI:1857632)

Bmi1^tm1Brn
Targeted Allele Detail

Summary

Symbol:	Bmi1^tm1Brn
Name:	Bmi1 polycomb ring finger oncogene; targeted mutation 1, Anton Berns
MGI ID:	MGI:1857632
Synonyms:	bmi-1-, Bmi1^-
Gene:	Bmi1 Location: Chr2:18681953-18691440 bp, + strand Genetic Position: Chr2, 12.9 cM
Alliance:	Bmi1^tm1Brn page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:17712
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The sequences encoding the ATG start codon, the zinc finger motif, and part of the helix-turn-helix motif were replaced either with a hygromycin-resistance cassette or one that conveyed neomycin-resistance. (J:17712)
Inheritance:		Semidominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	126 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	27 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bmi1^tm1Brn

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Bmi1 Mutation:	31 strains or lines available

References

Original:	J:17712 van der Lugt NM, et al., Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 1994 Apr 1;8(7):757-69
All:	84 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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