About   Help   FAQ
Pcgf2tm1Hko
Targeted Allele Detail
Summary
Symbol: Pcgf2tm1Hko
Name: polycomb group ring finger 2; targeted mutation 1, Haruhiko Koseki
MGI ID: MGI:1857633
Synonyms: mel-18-, mel18-
Gene: Pcgf2  Location: Chr11:97579649-97591323 bp, - strand  Genetic Position: Chr11, 61.06 cM, cytoband C1-C3
Alliance: Pcgf2tm1Hko page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33159
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced exon 5, which contains the transcriptional initiation codon and encodes the RING finger domain. RNAse protection assays demonstrated that a truncated transcript is produced from this allele in homozygous mice, but the authors predict that no functional protein can be translated. (J:33159)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 342 assay results
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pcgf2 Mutation:  48 strains or lines available
References
Original:  J:33159 Akasaka T, et al., A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton. Development. 1996 MAY;122(5):1513-1522
All:  19 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory