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Gbx2tm1.1Mrt
Targeted Allele Detail
Summary
Symbol: Gbx2tm1.1Mrt
Name: gastrulation brain homeobox 2; targeted mutation 1.1, Gail R Martin
MGI ID: MGI:1857634
Synonyms: Gbx2-, Gbx2deltahb
Gene: Gbx2  Location: Chr1:89855684-89858898 bp, - strand  Genetic Position: Chr1, 45.06 cM, cytoband C5-E1
Alliance: Gbx2tm1.1Mrt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42110
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: A neomycin resistance cassette and one loxP site were inserted into a BamH1 site in an intron; a second loxP site was inserted downstream of the stop codon. To obtain mice in which the floxed region of the gene was deleted, the authors crossed mice heterozygous for this mutation with mice that expressed Cre DNA recombinase in the egg or early embryo under control of promoter elements from the mouse Zp3 gene or human beta-actin gene, respectively. The resulting allele lacks the sequences encoding the homeobox. (J:42110, J:79431)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 133 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 42 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gbx2 Mutation:  27 strains or lines available
References
Original:  J:42110 Wassarman KM, et al., Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development. 1997 Aug;124(15):2923-34
All:  21 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory