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Edn1tm1Utj
Targeted Allele Detail
Summary
Symbol: Edn1tm1Utj
Name: endothelin 1; targeted mutation 1, University of Tokyo
MGI ID: MGI:1857637
Synonyms: EdnRA-, ET-1-
Gene: Edn1  Location: Chr13:42454952-42461466 bp, + strand  Genetic Position: Chr13, 20.82 cM
Alliance: Edn1tm1Utj page
Cardiovascular abnormalities in Edn1tm1Utj/Edn1tm1Utj mice at 18.5 dpc

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17694
Parent Cell Line:  A3-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: A neomycin resistance gene was inserted into exon 2, which encodes the mature peptide. RT-PCR analysis on RNA derived from homozygous embryos demonstrated that no detectable transcript was produced from this allele. Enzyme immunoassay tests confirmed that no active peptide was present in lung extracts of homozygous mice. (J:17694)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 65 assay results
In Structures Affected by this Mutation: 25 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Edn1 Mutation:  26 strains or lines available
References
Original:  J:17694 Kurihara Y, et al., Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1 [see comments]. Nature. 1994 Apr 21;368(6473):703-10
All:  31 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory