Prrx1<tm1Tex> Targeted Allele Detail MGI Mouse (MGI:1857640)

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Prrx1^tm1Tex
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Prrx1^tm1Tex
Name:	paired related homeobox 1; targeted mutation 1, University of Texas
MGI ID:	MGI:1857640
Synonyms:	Prx1^-, Prx1^LacZ, Prx-1^neo
Gene:	Prrx1 Location: Chr1:163072688-163141279 bp, - strand Genetic Position: Chr1, 70.53 cM
Alliance:	Prrx1^tm1Tex page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:25649
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A PGK-neomycin cassette was inserted into the 5' region of the homeobox domain. RT-PCR analysis failed to detect gene specific transcript in homozygous mutant animals. (J:25649)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	61 assay results
In Structures Affected by this Mutation:	39 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Prrx1 Mutation:	31 strains or lines available

References

Original:	J:25649 Martin JF, et al., The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages. Genes Dev. 1995 May 15;9(10):1237-49
All:	9 reference(s)

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