Met<tm1Cbm> Targeted Allele Detail MGI Mouse (MGI:1857655)

Met^tm1Cbm
Targeted Allele Detail

Summary

Symbol:	Met^tm1Cbm
Name:	met proto-oncogene; targeted mutation 1, Carmen Birchmeier
MGI ID:	MGI:1857655
Synonyms:	c-Met -, met^-
Gene:	Met Location: Chr6:17463799-17573979 bp, + strand Genetic Position: Chr6, 7.83 cM, cytoband A2
Alliance:	Met^tm1Cbm page

Cleft palate in Gab1^tm3Wbm/Gab1^tm3Wbm, Gab1^tm2Wbm/Gab1^tm2Wbm, Gab1^tm1Wbm/Gab1^tm1Wbm and Gab1^tm3Wbm/Gab1^tm3Wbm Met^tm1Cbm/Met⁺ mice, but not in Gab1^tm4Wbm/Gab1^tm4Wbm mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:28570
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin selection cassette replaced an exon encoding the invariant lysine 1108. RNAse protection analysis revealed that normal levels of a transcript lacking nucleotides 3254-3334 is produced from this allele, but no protein activity is detectable in an in vitro auto-kinase assay. (J:28570)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	28 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Met Mutation:	83 strains or lines available

References

Original:	J:28570 Bladt F, et al., Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud [see comments]. Nature. 1995 Aug 31;376(6543):768-71
All:	10 reference(s)

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