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Pitx1tm1Jdr
Targeted Allele Detail
Summary
Symbol: Pitx1tm1Jdr
Name: paired-like homeodomain transcription factor 1; targeted mutation 1, Jaques Drouin
MGI ID: MGI:1857659
Synonyms: Pitxtm1, Ptx1-
Gene: Pitx1  Location: Chr13:55972864-55984005 bp, - strand  Genetic Position: Chr13, 30.06 cM
Alliance: Pitx1tm1Jdr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52671
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 2 of this gene containing a homeodomain was replaced with a PGKneo-derived cassette via homologous recombination. Gene expression was not detected in Northern blot of mandibles from homozygous mutant embryos. (J:52671)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 76 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 22 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pitx1 Mutation:  11 strains or lines available
References
Original:  J:52671 Lanctot C, et al., Hindlimb patterning and mandible development require the Ptx1 gene. Development. 1999 May;126(9):1805-10
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory