Arnt<tm1Mcs> Targeted Allele Detail MGI Mouse (MGI:1857680)

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Arnt^tm1Mcs
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Arnt^tm1Mcs
Name:	aryl hydrocarbon receptor nuclear translocator; targeted mutation 1, M Celeste Simon
MGI ID:	MGI:1857680
Synonyms:	Arnt(-), Arnt-
Gene:	Arnt Location: Chr3:95341699-95404551 bp, + strand Genetic Position: Chr3, 40.74 cM
Alliance:	Arnt^tm1Mcs page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:39730
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A PGK-neomycin resistance cassette was inserted into the exon that encodes the basic-helix-loop-helix domain. (J:39730)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Arnt Mutation:	65 strains or lines available

References

Original:	J:39730 Maltepe E, et al., Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature. 1997 Mar 27;386(6623):403-7
All:	7 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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