Smad3<tm1Xfw> Targeted Allele Detail MGI Mouse (MGI:1857696)

Smad3^tm1Xfw
Targeted Allele Detail

Summary

Symbol:	Smad3^tm1Xfw
Name:	SMAD family member 3; targeted mutation 1, Xiao Fan Wang
MGI ID:	MGI:1857696
Synonyms:	Smad3^-, Smad3^null
Gene:	Smad3 Location: Chr9:63554049-63665276 bp, - strand Genetic Position: Chr9, 34.22 cM, cytoband D
Alliance:	Smad3^tm1Xfw page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:53948
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance cassette replaced the first exon and part of the first intron, including the initiating ATG codon. (J:53948)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Smad3 Mutation:	22 strains or lines available

References

Original:	J:53948 Datto MB, et al., Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol Cell Biol. 1999 Apr;19(4):2495-504
All:	30 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24