Smad4<tm1Cxd> Targeted Allele Detail MGI Mouse (MGI:1857698)

Smad4^tm1Cxd
Targeted Allele Detail

Summary

Symbol:	Smad4^tm1Cxd
Name:	SMAD family member 4; targeted mutation 1, Chu-Xia Deng
MGI ID:	MGI:1857698
Synonyms:	S4^-, smad4-, Smad4^ex8
Gene:	Smad4 Location: Chr18:73772080-73836851 bp, - strand Genetic Position: Chr18, 49.51 cM
Alliance:	Smad4^tm1Cxd page

Morphological and molecular analyses of Smad4^tm1Cxd/Smad4^tm1Cxd embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:46852
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A neomycin resistance cassette was inserted into exon 8 of the gene, which resulted in a 198 amino acid truncation of the protein's C-terminal end. (J:46852)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smad4^tm1Cxd

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Smad4 Mutation:	48 strains or lines available

References

Original:	J:46852 Yang X, et al., The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3667-72
All:	11 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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