Wnt7a<tm1Amc> Targeted Allele Detail MGI Mouse (MGI:1857704)

About Help FAQ

Wnt7a^tm1Amc
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Wnt7a^tm1Amc
Name:	wingless-type MMTV integration site family, member 7A; targeted mutation 1, Andrew P McMahon
MGI ID:	MGI:1857704
Synonyms:	Wnt-7a
Gene:	Wnt7a Location: Chr6:91340963-91388335 bp, - strand Genetic Position: Chr6, 40.45 cM
Alliance:	Wnt7a^tm1Amc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:23922
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A neomycin cassette was inserted into exon 2. Authors state that this is likely a null allele, but present no molecular evidence. (J:23922)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	95 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Wnt7a Mutation:	26 strains or lines available

References

Original:	J:23922 Parr BA, et al., Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature. 1995 Mar 23;374(6520):350-3
All:	32 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24