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Hif1atm1Jhu
Targeted Allele Detail
Summary
Symbol: Hif1atm1Jhu
Name: hypoxia inducible factor 1, alpha subunit; targeted mutation 1, Johns Hopkins University
MGI ID: MGI:1857719
Synonyms: Hif1a-
Gene: Hif1a  Location: Chr12:73948186-73994304 bp, + strand  Genetic Position: Chr12, 31.99 cM
Alliance: Hif1atm1Jhu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45554
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced exon 2, which encodes the bHLH domain, of the gene. (J:45554)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 60 assay results
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hif1a Mutation:  50 strains or lines available
References
Original:  J:45554 Iyer NV, et al., Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 1998 Jan 15;12(2):149-62
All:  33 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory