Htt<tm1Szi> Targeted Allele Detail MGI Mouse (MGI:1857722)

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Htt^tm1Szi
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Htt^tm1Szi
Name:	huntingtin; targeted mutation 1, Scott Zeitlin
MGI ID:	MGI:1857722
Synonyms:	Hdh-, Hdh^prex1
Gene:	Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
Alliance:	Htt^tm1Szi page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:29267
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1^c

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance cassette replaced a 2.8 kb fragment of the gene, which included the 5' flanking sequence, the entire first exon, and 0.6 kb of the 3' flanking intron. (J:29267)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Htt Mutation:	178 strains or lines available

References

Original:	J:29267 Zeitlin S, et al., Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nat Genet. 1995 Oct;11(2):155-63
All:	15 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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