Lig4<tm1Fwa> Targeted Allele Detail MGI Mouse (MGI:1857732)

Lig4^tm1Fwa
Targeted Allele Detail

Summary

Symbol:	Lig4^tm1Fwa
Name:	ligase IV, DNA, ATP-dependent; targeted mutation 1, Frederick W Alt
MGI ID:	MGI:1857732
Synonyms:	Lig4^-, LigIV^-
Gene:	Lig4 Location: Chr8:10020020-10027680 bp, - strand Genetic Position: Chr8, 4.52 cM
Alliance:	Lig4^tm1Fwa page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:50865
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance cassette replaced more than 50% of the coding sequences for the gene, removing the nucleotide sequences that encode amino acids 143 - 608 of the protein. (J:50865)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Lig4^tm1Fwa

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Lig4 Mutation:	46 strains or lines available

References

Original:	J:50865 Frank KM, et al., Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature. 1998 Nov 12;396(6707):173-7
All:	32 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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