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Chuktm1Aki
Targeted Allele Detail
Summary
Symbol: Chuktm1Aki
Name: conserved helix-loop-helix ubiquitous kinase; targeted mutation 1, Shizuo Akira
MGI ID: MGI:1857735
Synonyms: IKKalpha-
Gene: Chuk  Location: Chr19:44061774-44095919 bp, - strand  Genetic Position: Chr19, 36.71 cM
Alliance: Chuktm1Aki page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54315
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced an exon encoding subdomain VI of the kinase catalytic domain. Northern and western blot analysis of embryonic fibroblast cells derived from homozygous mice confirmed that expression of the mRNA and protein was abolished. (J:54315)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 11 assay results
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chuk Mutation:  51 strains or lines available
References
Original:  J:54315 Takeda K, et al., Limb and skin abnormalities in mice lacking IKKalpha [see comments]. Science. 1999 Apr 9;284(5412):313-6
All:  13 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory