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Gata2tm1Sho
Targeted Allele Detail
Summary
Symbol: Gata2tm1Sho
Name: GATA binding protein 2; targeted mutation 1, Stuart Orkin
MGI ID: MGI:1857743
Synonyms: GATA-2-
Gene: Gata2  Location: Chr6:88170873-88184014 bp, + strand  Genetic Position: Chr6, 39.2 cM
Alliance: Gata2tm1Sho page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:20316
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced 1 kb of sequence containing exon 2. RT-PCR analysis did not detect transcripts in differentiating embryoid bodies derived from homozygous ES cell lines. (J:20316)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 56 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata2 Mutation:  30 strains or lines available
References
Original:  J:20316 Tsai FY, et al., An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 1994 Sep 15;371(6494):221-6
All:  27 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory