Adam17<tm1Imx> Targeted Allele Detail MGI Mouse (MGI:1857753)

Adam17^tm1Imx
Targeted Allele Detail

Summary

Symbol:	Adam17^tm1Imx
Name:	a disintegrin and metallopeptidase domain 17; targeted mutation 1, Immunex
MGI ID:	MGI:1857753
Synonyms:	ADAM17^deltaZn, ADAM17^Zndelta, TACE-, tace^deltaZn
Gene:	Adam17 Location: Chr12:21373510-21423633 bp, - strand Genetic Position: Chr12, 8.3 cM
Alliance:	Adam17^tm1Imx page

Adam17^tm1Imx/Adam17^tm1Imx embryos develop internal hemorrhage

Show the 4 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:38527
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		A neomycin cassette replaced a 1.2kb fragment of the gene, which encodes the zinc-binding domain. (J:38527)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

20 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Adam17 Mutation:	64 strains or lines available

References

Original:	J:38527 Black RA, et al., A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature. 1997 Feb 20;385(6618):729-33
All:	42 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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