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Ikbkbtm1Trk
Targeted Allele Detail
Summary
Symbol: Ikbkbtm1Trk
Name: inhibitor of kappaB kinase beta; targeted mutation 1, Tularik Inc
MGI ID: MGI:1857761
Synonyms: IKK-beta-
Gene: Ikbkb  Location: Chr8:23149228-23196605 bp, - strand  Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
Alliance: Ikbkbtm1Trk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55680
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: Insertion of a neomycin resistance cassette disrupted exon 2 of the gene, which encodes the ATP binding site of the kinase domain. (J:55680)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbkb Mutation:  56 strains or lines available
References
Original:  J:55680 Tanaka M, et al., Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice. Immunity. 1999 Apr;10(4):421-9
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory