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Rce1tm1Kim
Targeted Allele Detail
Summary
Symbol: Rce1tm1Kim
Name: Ras converting CAAX endopeptidase 1; targeted mutation 1, Edward Kim
MGI ID: MGI:1857763
Synonyms: Rce1-
Gene: Rce1  Location: Chr19:4672619-4675669 bp, - strand  Genetic Position: Chr19, 4.07 cM
Alliance: Rce1tm1Kim page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53886
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The sequence encoding amino acids 115 through 329, the carboxy-terminal two-thirds of the protein, was replaced with a floxed neomycin selection cassette. The inserted cassette was not excised by cre-recombinase. (J:53886)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 39 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rce1 Mutation:  14 strains or lines available
References
Original:  J:53886 Kim E, et al., Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. J Biol Chem. 1999 Mar 26;274(13):8383-90
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory