Ppara<tm1Gonz> Targeted Allele Detail MGI Mouse (MGI:1857774)

Ppara^tm1Gonz
Targeted Allele Detail

Summary

Symbol:	Ppara^tm1Gonz
Name:	peroxisome proliferator activated receptor alpha; targeted mutation 1, Frank J Gonzalez
MGI ID:	MGI:1857774
Synonyms:	mPPARalpha-, PPAR-alpha-, PPARalpha-, PPARalpha-null, Pparat^niJGonz
Gene:	Ppara Location: Chr15:85619184-85687020 bp, + strand Genetic Position: Chr15, 40.42 cM
Alliance:	Ppara^tm1Gonz page

Accumulation of intracellular lipid in the liver of fasted Ppara^tm1Gonz/Ppara^tm1Gonz mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:25516
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A neomycin resistance cassette replaced 83 bp of the coding sequence in exon 8. Northern blot analysis did not detect a transcript of wild-type size on RNA derived from liver of homozygous mice. An larger abnormal transcript was detected. Western blot analysis did not detect PPARA protein in extracts derived from livers of homozygous mice. (J:25516, J:91859)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	132 assay results 12 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ppara^tm1Gonz

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available Cell Lines: 0 lines available
Carrying any Ppara Mutation:	44 strains or lines available

References

Original:	J:25516 Lee SS, et al., Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol. 1995 Jun;15(6):3012-22
All:	400 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24