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Notch2tm1Yha
Targeted Allele Detail
Summary
Symbol: Notch2tm1Yha
Name: notch 2; targeted mutation 1, Yoshio Hamaha
MGI ID: MGI:1857783
Synonyms: N2LacZ, Notch2m
Gene: Notch2  Location: Chr3:97920854-98057683 bp, + strand  Genetic Position: Chr3, 42.42 cM
Alliance: Notch2tm1Yha page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55841
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: An in-frame lacZ-neomycin resistance cassette replaced the exons encoding the second through the sixth ankyrin repeats. This allele expresses a beta galactosidase fusion protein. (J:55841)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 48 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch2 Mutation:  99 strains or lines available
Notes
In aggregation chimeras with wild-type tetraploid embryos, mutant embryos develop normally until E12.5 but die before E13.5. Chimeric placentas show restored maternal blood sinus formation. (J:120082).
References
Original:  J:55841 Hamada Y, et al., Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality. Development. 1999 Aug;126(15):3415-24
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
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